The molecular structure of a pharmaceutical compound is seen on a dark non-descript background, wisps of outlines begin to form around the structure, building the space-filling visual model of the compound.

Ominous glowing red neoplastic cells form a tumor within a dark tissue environment; new blood vessels resulting from angiogenesis feed the growing tumor.

Microtubule polymers, regulated by small protein compounds, extend outward from a cluster of mitotic spindles during mitosis.

MLN 8237 (alisertib) Mechanism of Disease Animation

CHALLENGE:
The Aurora A kinase protein plays a key role in allowing entry and progression through mitosis. Several studies have shown that this protein is over-expressed in solid tumors and hematologic malignancies. We needed to explain the metabolic process of the pathway and its potential link to cancer progression in a short amount of time.

TRANSFORMATION:
Beautifully rendered in 3D, our mechanism of disease animation explains how cells divide when they undergo mitosis and the changes that can potentially lead to cancer development.

RESULT:
The result is both educational and visually dynamic. The animation captures the role of Aurora A kinase using a storyline that is short enough to sustain the viewer’s attention, yet long enough to ensure the message is retained.

ClientTakeda OncologyAudienceHealthcare professionalsYear2013Winner ofAssociation of Medical Illustrators (Award of Excellence)

MLN 8237 (alisertib) Mechanism of Disease Animation

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